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Christopher M O'Connor Selected Research

Adenosine (Adenocard)

8/2015Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging.
10/2013Learning from recent trials and shaping the future of acute heart failure trials.
9/2013Is thrombosis a contributor to heart failure pathophysiology? Possible mechanisms, therapeutic opportunities, and clinical investigation challenges.
3/2012The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT.
5/2011Effects of the adenosine A1 receptor antagonist rolofylline on renal function in patients with acute heart failure and renal dysfunction: results from PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function).
10/2010Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.
10/2008The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment.

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Christopher M O'Connor Research Topics

Disease

341Heart Failure
12/2022 - 01/2002
35Myocardial Infarction
01/2022 - 01/2002
21Atrial Fibrillation
02/2022 - 02/2007
20Cardiomyopathies (Cardiomyopathy)
12/2022 - 07/2002
19Dyspnea (Shortness of Breath)
01/2020 - 07/2005
18Left Ventricular Dysfunction
12/2019 - 07/2002
17Coronary Artery Disease (Coronary Atherosclerosis)
12/2022 - 07/2002
12Hypertension (High Blood Pressure)
12/2019 - 02/2004
12Myocardial Ischemia (Ischemic Heart Diseases)
11/2017 - 08/2002
11Acute Coronary Syndrome
11/2012 - 10/2002
10Diabetes Mellitus
01/2021 - 01/2004
10Weight Loss (Weight Reduction)
03/2017 - 10/2007
9Hypotension (Low Blood Pressure)
01/2022 - 03/2002
9Anemia
11/2021 - 09/2003
9Heart Diseases (Heart Disease)
12/2016 - 07/2006
7Chronic Obstructive Pulmonary Disease (COPD)
01/2020 - 04/2012
7Stroke (Strokes)
12/2019 - 03/2003
7Coronary Disease (Coronary Heart Disease)
12/2019 - 07/2002
7Cardiovascular Diseases (Cardiovascular Disease)
06/2019 - 07/2002
6Edema (Dropsy)
01/2020 - 10/2005
6Inflammation (Inflammations)
10/2017 - 09/2013
5Major Depressive Disorder (Major Depressive Disorders)
10/2018 - 12/2003
5Sudden Death
01/2017 - 05/2003
5Systolic Heart Failure
10/2014 - 07/2008
5Body Weight (Weight, Body)
12/2012 - 04/2004
5Unstable Angina
03/2005 - 01/2002
4Disease Progression
01/2018 - 10/2007
4Renal Insufficiency (Renal Failure)
12/2015 - 09/2004
4Hyponatremia
09/2015 - 10/2007
3Chronic Disease (Chronic Diseases)
01/2022 - 11/2014
3Type 2 Diabetes Mellitus (MODY)
12/2019 - 07/2010
3Ventricular Tachycardia
01/2019 - 05/2003
3Cardiac Sudden Death (Sudden Cardiac Arrest)
01/2018 - 05/2009
3Fibrosis (Cirrhosis)
03/2015 - 01/2014

Drug/Important Bio-Agent (IBA)

64Brain Natriuretic Peptide (Natrecor)FDA Link
01/2022 - 01/2002
43Biomarkers (Surrogate Marker)IBA
03/2022 - 01/2002
28DiureticsIBA
01/2021 - 04/2004
21Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2022 - 05/2003
19vericiguatIBA
01/2022 - 01/2018
18pro-brain natriuretic peptide (1-76)IBA
03/2022 - 10/2009
18rolofyllineIBA
11/2019 - 10/2008
17CreatinineIBA
01/2020 - 01/2004
15Angiotensin Receptor AntagonistsIBA
11/2019 - 01/2007
15Urea (Carbamide)FDA LinkGeneric
01/2017 - 02/2007
13NitrogenIBA
01/2017 - 05/2008
12Mineralocorticoid Receptor AntagonistsIBA
12/2019 - 02/2010
11Natriuretic PeptidesIBA
01/2019 - 09/2009
11Sertraline (Zoloft)FDA LinkGeneric
09/2015 - 08/2002
10Purinergic P1 Receptor AntagonistsIBA
11/2019 - 01/2010
10Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA
11/2018 - 10/2007
10SodiumIBA
08/2015 - 05/2005
9Hemoglobins (Hemoglobin)IBA
11/2021 - 01/2006
8Pharmaceutical PreparationsIBA
01/2018 - 10/2002
8Furosemide (Lasix)FDA LinkGeneric
02/2016 - 06/2010
8Antidepressive Agents (Antidepressants)IBA
08/2010 - 01/2002
8Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
02/2010 - 06/2002
7TolvaptanFDA Link
01/2018 - 02/2003
7tezosentanIBA
01/2017 - 10/2002
7Adenosine (Adenocard)FDA LinkGeneric
08/2015 - 10/2008
7Carvedilol (Coreg)FDA LinkGeneric
08/2011 - 01/2002
7Clopidogrel (Plavix)FDA Link
03/2009 - 03/2003
7Milrinone (Primacor)FDA LinkGeneric
05/2008 - 03/2002
6EscitalopramFDA Link
11/2017 - 01/2012
6TroponinIBA
01/2017 - 01/2010
5bucindololIBA
02/2022 - 03/2005
5C-Reactive ProteinIBA
02/2016 - 03/2004
4Soluble Guanylyl CyclaseIBA
10/2020 - 01/2018
4Digoxin (Digitek)FDA LinkGeneric
12/2019 - 08/2005
4Vasopressins (Vasopressin)IBA
01/2018 - 05/2010
4Troponin IIBA
01/2017 - 06/2004
4Adenosine A1 ReceptorIBA
11/2016 - 10/2008
4Warfarin (Coumadin)FDA LinkGeneric
09/2013 - 03/2003
4Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
06/2010 - 08/2003
4Valsartan (Vals)FDA Link
10/2005 - 05/2003
3Angiotensin Receptors (Angiotensin II Receptor)IBA
11/2021 - 01/2018
3Neprilysin (Neutral Endopeptidase)IBA
11/2021 - 01/2018
3AlbuminsIBA
05/2021 - 01/2014
3ChloridesIBA
05/2021 - 08/2015
3Biological ProductsIBA
01/2021 - 08/2013
3PotassiumIBA
11/2019 - 09/2014
3Adrenergic Receptors (Adrenergic Receptor)IBA
01/2018 - 03/2013
3Endothelin Receptors (Endothelin Receptor)IBA
01/2017 - 07/2005
3MicroRNAs (MicroRNA)IBA
12/2016 - 01/2016
3Vasoconstrictor AgentsIBA
03/2016 - 07/2005
3Endothelin-1 (Endothelin 1)IBA
03/2016 - 07/2005
3Anti-Bacterial Agents (Antibiotics)IBA
02/2016 - 09/2003
3Torsemide (Demadex)FDA LinkGeneric
02/2016 - 03/2015
3Galectin 3 (LGALS3)IBA
06/2014 - 01/2012
3Fibrinolytic Agents (Antithrombotic Agents)IBA
09/2013 - 04/2004

Therapy/Procedure

156Therapeutics
12/2022 - 01/2002
36Patient Readmission
01/2021 - 09/2003
21Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/2017 - 05/2003
15Length of Stay
01/2018 - 05/2004
12Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/2022 - 01/2002
12Cardiac Resynchronization Therapy
08/2014 - 04/2009
9Percutaneous Coronary Intervention
01/2022 - 04/2007
7Palliative Care (Palliative Therapy)
01/2022 - 09/2012
5Catheters
10/2011 - 10/2005
3Defibrillators (Defibrillator)
01/2021 - 04/2005
3Secondary Prevention
01/2018 - 09/2003